解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Bioresponsive poly(amidoamine)s (PAA)s are currently under development as endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first time, small-angle neutron scattering (SANS) is used to systematically investigate the pH-dependent conformational change of an endosomolytic polymer, the...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049936g
更新日期:2004-07-01 00:00:00
abstract::Surface-immobilized liposome layers are of interest for various potential applications such as localized drug delivery, but their characterization is challenging. We have employed an AFM method and fluorescent dye release to analyze anchored liposomes. In addition, we studied whether the liposomes are surface-bound so...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049941k
更新日期:2004-07-01 00:00:00
abstract::A novel poly(epsilon-caprolactone)-organosiloxane hybrid material containing calcium salt (Si-O-PCL) was prepared and evaluated as a bioactive and degradable bone substitute material. The Si-O-PCL hybrid was synthesized by the end-capping of 3-isocyanatopropyl triethoxysilane with alpha,omega-hydroxyl PCL following so...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm049885n
更新日期:2004-07-01 00:00:00
abstract::Spidroins, the major silk proteins making up the spider's dragline silk, originate in two distinct tissue layers (A and B) in the spider's major ampullate gland. Formation of the complex thread from spidroins occurs in the lumen of the duct connected to the gland. Using pH-sensitive microelectrode probes, we showed th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034307c
更新日期:2004-05-01 00:00:00
abstract::Fluorescence and circular dichroism spectroscopy were used to monitor the conformational transition of regenerated Bombyx mori silk fibroin (RSF) in aqueous solutions under different conditions. According to the analysis of fluorescence spectra using anilinonaphthalene-8-sulfonic acid magnesium salt (ANS) as an extern...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0343848
更新日期:2004-05-01 00:00:00
abstract::The C-termini of Spidroins produced in the major and minor ampullate glands of spiders are highly conserved. Despite this conservation, no corresponding peptides have been identified in the spinning dopes or the silk filaments so far. To prove their presence or absence, polyclonal antibodies derived against fusion pro...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034378b
更新日期:2004-05-01 00:00:00
abstract::Saccharide-functionalized shell cross-linked (SCK) polymer micelles designed as polyvalent nanoscaffolds for selective interactions with receptors on Gram negative bacteria were constructed from mixed micelles composed of poly(acrylic acid-b-methyl acrylate) and mannosylated poly(acrylic acid-b-methyl acrylate). The m...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0344710
更新日期:2004-05-01 00:00:00
abstract::Oxidative coupling of phenol-containing precursor poly(amino acid)s, poly(alpha-glutamine), poly(alpha/beta-asparagine), and poly(gamma-glutamine) derivatives, has been examined to produce a new class of soluble poly(amino acid)s. Under appropriate reaction conditions, the Fe-salen and HRP catalysts efficiently induce...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034490+
更新日期:2004-05-01 00:00:00
abstract::The mycobacterial cell wall is extraordinarily thick and tight consisting mainly of (1). long chain fatty acids, the mycolic acids, and (2). a unique polysaccharide, arabinogalactan (AG). These two chemical constituents are covalently linked through ester bonds. Minnikin (The Biology of the Mycobacteria; Academic: Lon...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034514c
更新日期:2004-05-01 00:00:00
abstract::Neutron reflectometry was used to investigate effects of calcium ions on the interfacial behavior of beta-casein at the silicon oxide-aqueous solution interface. The structural characteristics of the adsorbed layer were determined from reflectivity curves fitted to three- and two-layer optical models. The results show...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034301n
更新日期:2004-03-01 00:00:00
abstract::Enzymatic hydrolysis of selected copolymers of cellulose diacetate-graft-poly(L-lactide)s (CDA-g-PLLAs) were conducted with proteinase K for film specimens, which were solely quenched from the molten state or, further, annealed at temperatures below or above their glass transition temperatures. The hydrolysis rates de...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034453i
更新日期:2004-03-01 00:00:00
abstract::A way to convert the volume change of a biochemo-mechanical gel into the change in liquid column length was developed. Our trial sensor device consisted of a small compartment for incorporating the gel, a flow channel with a filled dye solution, and a poly(dimethylsiloxane) (PDMS) diaphragm by which the gel and the dy...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034331q
更新日期:2004-03-01 00:00:00
abstract::Spherulites of poly(L-lactic acid) (PLLA) and of its blends with atactic poly(3-hydroxybutyrate) (a-PHB, from 10 to 75 wt %) were investigated by microfocus X-ray diffraction using synchrotron radiation. Radial scans in 5 microm steps with 3 microm beam diameter were performed. In PLLA, tens of identical diffraction i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0343951
更新日期:2004-03-01 00:00:00
abstract::Characterization of poly-3-hydroxybutyric acid (PHB) and poly-3-hydroxybutyric-co-valeric acid (PHBV, 13% valerate) in chloroform was performed using size exclusion chromatography coupled to a multi-angle light scattering detector (SEC-MALS). Absolute molar mass averages, molar mass distribution, and the radius of gyr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm030073l
更新日期:2004-03-01 00:00:00
abstract::Horseradish peroxidase-catalyzed polymerization of cardanol in aqueous organic solvent was investigated in the presence of a redox mediator. Cardanol is a phenol derivative from a renewable resource mainly having a C15 unsaturated hydrocarbon chain with mostly 1-3 double bonds at a meta position. Unlike soybean peroxi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034325u
更新日期:2004-01-01 00:00:00
abstract::Binding of a poly(amido amine) dendrimer with salmon testes DNA in an aqueous solution of 0.01 M NaCl at pH 6.5 has been investigated. It was shown from the physicochemical experiments of static light scattering and ultra-violet and circular dichroism spectroscopy that at a 0.2 mixing ratio of dendrimer/DNA (number ra...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034239u
更新日期:2004-01-01 00:00:00
abstract::The ability of microbally produced poly(gamma,d-glutamic acid) to form stable polyelectrolyte-opposite charged surfactant complexes was investigated. A sonicated sample of polyacid with a molecular weight about 10(5) Da and a content of d enantiomer higher than 90% was used in this study. Nearly stoichiometric complex...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034267c
更新日期:2004-01-01 00:00:00
abstract::Glycopolymer-polypeptide triblock copolymers of the structure, poly(l-alanine)-b-poly(2-acryloyloxyethyl-lactoside)-b-poly(l-alanine) (AGA), have been synthesized by sequential atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP). Controlled free radical polymerization of 2-O-acryloyl-oxye...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0343500
更新日期:2004-01-01 00:00:00
abstract::A new series of cationic, thermo-sensitive, and biodegradable poly(L-lactide)-poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PLLA-PEOz-PLLA) triblock copolymers were synthesized by ring-opening polymerization. With increasing molecular weight and crystallinity of hydrophobic PLLA blocks, the critical micellization concent...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034190s
更新日期:2003-11-01 00:00:00
abstract::We report an enzyme-based method for the in situ entrapment of cells within a biopolymeric hydrogel matrix. Specifically, we used a calcium-independent microbial transglutaminase that is known to cross-link proteins and observed that it catalyzes the formation of gels from a pre-gel solution containing 10% gelatin and...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034145k
更新日期:2003-11-01 00:00:00
abstract::Amphiphilic ABC triblock copolymers composed of monomethoxy-capped poly(ethylene glycol) (MPEG), poly(2-(dimethylamino)ethyl methacrylate) (DMA), and poly(2-(diethylamino)ethyl methacrylate) (DEA) have been synthesized by atom transfer radical polymerization (ATRP). These copolymers dissolve molecularly in acidic aque...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm030026t
更新日期:2003-11-01 00:00:00
abstract::We investigate lysozyme-lysozyme and lysozyme-salt interactions in electrolyte solutions using a molecular-thermodynamic model. An equation of state based on the statistical mechanical perturbation theory is applied to describe the interactions. The perturbation term includes a new square-well potential of mean force,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0300406
更新日期:2003-11-01 00:00:00
abstract::The formation of protein-polymer complexes was studied in an aqueous system using dynamic light scattering (DLS) and static light scattering (SLS) as the main experimental tools. Human serum albumin (HSA) was used as a protein and complexed with four representative water-soluble polymers: poly(N-isopropylacrylamide) (...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0341935
更新日期:2003-11-01 00:00:00
abstract::This paper describes the synthesis and evaluation of a series of multifunctional poly-l-glutamic acid derivatives that can be used as vectors for gene delivery. They readily form polyelectrolyte complexes with DNA, resulting in a reduced surface charge and size of the DNA. The formation of a polymer-DNA complex and th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034014j
更新日期:2003-09-01 00:00:00
abstract::Chitosan-dendrimer hybrids having various functional groups such as carboxyl, ester, and poly(ethylene glycol) groups were prepared successfully using dendrimer acetal by reductive N-alkylation. The synthetic procedure could be accomplished by one-step reaction without organic solvent. The degree of substitution of de...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm030021w
更新日期:2003-09-01 00:00:00
abstract::Reversible stereoselective complexes were spontaneously obtained from mixing acetonitrile solutions of enatiomeric d-poly(lactic acid) (d-PLA), l-poly(lactic acid) (l-PLA), and leuprolide, a l-configured nonapeptide LHRH analogue. The complex spontaneously aggregated and precipitated in high yields (>90%) from acetoni...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0300249
更新日期:2003-09-01 00:00:00
abstract::Amphiphilic random, gradient, and block copolymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and n-butyl methacrylate (BMA) were synthesized by atom transfer radical polymerization (ATRP) in water/2-propanol mixtures using a methoxy-poly(ethylene glycol) (MPEG) (M(n) = 2000) macroinitiator. Kinetic studies indic...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm034126a
更新日期:2003-09-01 00:00:00
abstract::Crystal conversion of beta-chitin to alpha-chitin by aq. NaOH treatment was studied for a highly crystalline beta-chitin sample from diatom spine. The minimum NaOH concentration to cause swelling was between 25% and 30% w/w. The alkali-swollen material was poorly crystalline and was regenerated as alpha-chitin on wash...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0257513
更新日期:2003-07-01 00:00:00
abstract::In this paper, we describe the preparation and characterization of Langmuir and Langmuir-Blodgett (LB) monolayers of the enzyme organophosphorus acid anhydrolase (OPAA). Langmuir films of OPAA were characterized on different subphases, such as phosphate, ammonium carbonate, and bis-tris-propane buffers. Monolayers at ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025775+
更新日期:2003-07-01 00:00:00
abstract::In the present contribution, two-dimensional ATR-FTIR spectroscopy was used to study the diffusion of water in poly(epsilon-caprolactone) (PCL). In the spectral region of the nu(OH) stretching vibration of water, four absorption bands (3635, 3560, 3411, and 3220 cm(-1)) can be identified. The higher wavenumber band pa...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0340624
更新日期:2003-07-01 00:00:00
abstract::To devise a sensitive cellulase assay based on substrates having most of the physical characteristics of native cellulose, 5-(4,6-dichlorotriazinyl)aminofluorescein (DTAF) was used as a grafting agent to prepare suspensions of fluorescent microfibrils from bacterial cellulose. These suspensions were digested by a seri...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020076i
更新日期:2003-05-01 00:00:00
abstract::The intermolecular interactions of lignin with a hydrophilic polymer, poly(vinyl alcohol) (PVA), were studied using thermal analyses and FT-IR spectroscopy of a series of PVA/hardwood kraft lignin blend fibers prepared by thermal extrusion. Although two phases are observed in this blend system, some of the lignin was ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025727p
更新日期:2003-05-01 00:00:00
abstract::Physicochemical properties of a homogeneous series of chitosans with different degrees of acetylation and almost the same degree of polymerization were investigated in an ammonium acetate buffer. Techniques such as interferometry, static light scattering (in batch or coupled on line with a chromatographic system), and...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025724c
更新日期:2003-05-01 00:00:00
abstract::The interaction of iron with water-soluble polymer chitosan and monomer d-glucosamine is investigated by Mössbauer spectroscopy. The 4.2 K Mössbauer spectrum of Fe-water-soluble chitosan complex indicates the presence of a magnetic pattern and a quadrupole doublet, and analysis of the spectral data leads to the conclu...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020131n
更新日期:2003-05-01 00:00:00
abstract::The copolymer of methyl methacrylate (MMA) and 2-[2',3',5'-triiodobenzoyl]oxoethyl methacrylate (1), ratio 3:1 (mass:mass), was prepared via a free-radical polymerization in bulk. The copolymer (M(w) = 97.8 kD and M(n) = 41.5 kD) was dissolved in chloroform and subsequently transformed into beads with a diameter in th...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm030002m
更新日期:2003-05-01 00:00:00
abstract::The shear rheology of a microcrystalline cellulose dissolved in a 9% NaOH aqueous solution was studied in the steady and oscillatory modes. The cellulose-(9% NaOH-H(2)O) mixtures show not to be true solutions. In the dilute regime, with cellulose concentration below 1%, the rheological behavior is typical of the one o...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm020100s
更新日期:2003-03-01 00:00:00
abstract::Acrylic acid (AAc) has been utilized to introduce reactive carboxyl groups to a temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). However, AAc introduction shifts the copolymer phase transition temperatures higher and dampens the steep homopolymer phase transition with increasing AAc content. We pr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025692t
更新日期:2003-03-01 00:00:00
abstract::Electrospun poly(glycolide-co-lactide) (PLA10GA90, LA/GA ratio 10/90) biodegradable nanofiber membranes possessed very high surface area to volume ratios and were completely noncrystalline with a relatively lowered glass transition temperature. These characteristics led to very different structure, morphology, and pro...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025717o
更新日期:2003-03-01 00:00:00
abstract::The aim of this paper is to define optimal conditions for the extraction of chitin from shrimp shells. The kinetics of both demineralization and deproteinization with, in the latter case, the role of temperature are studied. The characterization of the residual calcium and protein contents, the molecular weights, and ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm025602k
更新日期:2003-01-01 00:00:00
abstract::Poly(3-(tert-butoxycarbonyl)-N-vinyl-2-pyrrolidone) has been synthesized and characterized by gel permeation chromatography, Fourier transform infrared spectroscopy, NMR spectroscopy, and thermal analysis. The polymer is a chemically amplified photoresist. Arrays of lines with 25 microm width and 25 microm spacing wer...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm0256505
更新日期:2003-01-01 00:00:00